A B S T R A C T The chief purpose of this work was to synthesise and find out the anti-oxidant and antimicrobial activities of novel 3-(2-substituted)-1H-indol-3-yl)-1-(thiophen-2yl)prop-2-en-1one chalcone derivatives. These derivatives were prepared by performing Claisen-Schmidt condensation reaction of 1-(thiophen-2yl)ethanone and 2 substituted 1H-indole-3carbaldehyde with constant stirring (approximately for 3 hours) in the presence of ethanol and potassium hydroxide. The newly synthesised

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... mpounds' anti-oxidant and antimicrobial activities have been identified by using DPPH radical scavenging assay, zone of inhibition and minimum inhibitory concentration. Most of the prepared compounds had shown excellent anti-oxidant and anti-microbial activities as compared to the standard drugs like Ascorbic acid, Ciprofloxacin and Fluconazole. Among the synthesised compounds, compounds 4e, 4h and 4a showed remarkable activity at low concentration. Therefore, these compounds deserve further research.