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Calcium-regulated DNA Binding and Oligomerization of the Neuronal Calcium-sensing Protein, Calsenilin/DREAM/KChIP3
2001
Journal of Biological Chemistry
Calsenilin/DREAM/KChIP3, a member of the recoverin branch of the EF-hand superfamily, interacts with presenilins, serves as a calcium-regulated transcriptional repressor, and interacts with A-type potassium channels. Here we report physicochemical characterization of calcium binding, oligomerization, and DNA binding of human calsenilin/DREAM/KChIP3. Equilibrium Ca 2؉ binding measurements indicate that the protein binds 3 Ca 2؉ with a dissociation constant of 14 M and a Hill coefficient of 0.7.
doi:10.1074/jbc.m105842200
pmid:11535596
fatcat:ekbrgrlrsvgxjiygid3r5zfkeq