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Establishment of a Split-LUX Assay to Determine Protein Interaction of the BMP-Receptor mAlk2R206H (FOP Mutant) with the Rapamycin-Associated Protein FKBP12
2014
unpublished
Fibrodysplasia Ossificans Progressiva (FOP) is a devastating disease caused by various mutations in the BMP receptor mAlk2, which leads to heterotopic ossification. The mutation this thesis is focusing on is an arginine to histidine substitution on position 206 in the GS (glycine-serine-motif) domain of the mAlk2 receptor. Due to this mutation, the receptors inhibition is drastically altered, leading to constitutive activity and permanently activated BMP (bone morphogenic protein) signaling,
doi:10.25365/thesis.40068
fatcat:bqwkph2lvreona2xkj6ik33nla