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The beta 3-adrenergic receptor inhibits insulin-stimulated leptin secretion from isolated rat adipocytes
1996
Endocrinology
Various model systems have been used to study the expression of the recently cloned ol, gene, leptin. Here we report that freshly isolated rat white adipocytes incubated with htsulln release leptin in a rapid and concentrationdependent manner (EC, of 0.221 f .075 nM). Insulinstimulated lepthr release could be detected as early as 30 mm and a maximal 2-3 fold effect was produced by 10 nM hrsulin. The effect of insulin was completely blocked by simultaneous activation of cAMP-dependent protein
doi:10.1210/en.137.9.4054
pmid:8756584
fatcat:qutirr65rbfandan3uglh53hou