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The uptake of radioiodinated mouse and human serum albumin (HSA) by macrophages from non-immunized CBA mice depended on the degree of aggregation of the albumin, and not on cytophilic antibody on the surface of the cell. Autologous and heterologous albumin of comparable physical states were taken up and metabolized equally by macrophages. The HSA taken up by macrophages was rapidly catabolized, except for a small amount that remained associated with the cell both intracellularly and on thedoi:10.4049/jimmunol.107.2.331 fatcat:euty2mazujhgffydsexz6x4psu