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Background: Drug eruption may occur when HIV patients receive antiviral treatment. However, Lamivudine-induced repeated drug eruption has rarely been reported among the antiretrovirals.Case presentation: We report a rare case of repeated drug eruption caused by Lamivudine. The treatment history of this patient was interesting. Patients developed repeated drug eruption regardless of treatment TDF+3TC+EFV or TDF+3TC+LPV/r. The viral load of the patient in 2016 and 2017 was 58 copies/ml and < 50doi:10.21203/rs.3.rs-167709/v1 fatcat:vej7padrcjhjxmiprv2z37ovty