Background: Drug eruption may occur when HIV patients receive antiviral treatment. However, Lamivudine-induced repeated drug eruption has rarely been reported among the antiretrovirals.Case presentation: We report a rare case of repeated drug eruption caused by Lamivudine. The treatment history of this patient was interesting. Patients developed repeated drug eruption regardless of treatment TDF+3TC+EFV or TDF+3TC+LPV/r. The viral load of the patient in 2016 and 2017 was 58 copies/ml and < 50

more »

... pies/ml respectively by TDF+LPV/r with no drug eruption, but antiviral failure was found in 2018. This patient was successfully treated with TDF+LPV/r+DTG in 2019 and 2020.Conclusions: Through repeated drug eruption of the patient, we found that the allergenic drug is Lamivudine. The viral load of the patient can be effectively controlled by TDF+LPV/r+DTG.