Spatio-temporal dynamics of EEG features during sleep in major depressive disorder after treatment with escitalopram:A pilot study [post]

2019 unpublished
Previous studies have shown escitalopram is related to sleep quality. However, effects of escitalopram on dynamics of electroencephalogram (EEG) features especially during different sleep stages have not been reported. This study may help to reveal pharmacological mechanism underlying escitalopram treatment. Methods: The spatial and temporal responses of patients with major depressive disorder (MDD) to escitalopram treatment were analyzed in this study. Eleven MDD patients and eleven healthy
more » ... trol subjects who completed whole tests were included in the final statistics. Six-channel sleep EEG signals were acquired during sleep. Power spectrum and nonlinear dynamics were used to analyze the spatio-temporal dynamics features of the sleep EEG after escitalopram treatment. Results: For temporal dynamics: after treatment, there was a significant increase in the relative energy (RE) of band, accompanied by a significant decrease in the RE of band. Lempel-Ziv complexity and C0 complexity values were significantly lower. EEG changes at different sleep stages also showed the same regulation as the whole sleep process. For spatio dynamics: after treatment, the EEG response of the left and right hemisphere showed asymmetry. Further analysis of brain region-specific targets found that the frontal cortex showed a more intense EEG response with escitalopram treatment than central and occipital cortices. Conclusions: These findings may contribute to a comprehensive understanding of the pharmacological mechanism of escitalopram in the treatment of depression. Background Major depressive disorder (MDD) is one of the most common diseases worldwide and is responsible for premature deaths and disability (Baghai et al. 2018). In the past, MDD
doi:10.21203/rs.2.16941/v1 fatcat:olde2kkvq5elvexrukwqc2rgfq