Cyclic Cushing's Disease in Long-Term Remission with a Daily Low Dose of Bromocriptine

Masahiro ADACHI, Ryoichi TAKAYANAGI, Toshihiko YANASE, Yoshiyuki SAKAI, Shoichiro IKUYAMA, Hiroyuki NAKAGAKI, Yoshiyuki OSAMURA, Naoko SANNO, Hajime NAWATA
1996 Internal medicine (Tokyo. 1992)  
A 56-year-old male patient with cyclic Cushing's disease remained in a state of remission for more than one year with a relatively low dose of bromocriptine (2.5-3.75 mg/day). It has been reported that bromocriptine treatment for cyclic Cushing's disease induces only a transient remission; in the most effective cases, a relatively high dose (40 mg/day) was necessary. In the hypercortisolemic state, plasma adrenocorticotropic hormone (ACTH)and serum cortisol were not suppressed by dexamethasone
more » ... nd did not respond to corticotropin^releasing factor (CRF). An antehypophysectomy was not effective, even though the resected tissue contained ACTH-positive microadenomas. The present observations thus indicate the effectiveness of bromocriptine for some patients with this rare disorder.
doi:10.2169/internalmedicine.35.207 fatcat:oaxsl4jfhrhbfj67msaxtfkttq