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C4d staining in post-reperfusion renal biopsy is not useful for the early detection of antibody-mediated rejection when CDC crossmatching is negative

E. David-Neto, D. S. R. David, G. F. Ginani, H. Rodrigues, P. S. Souza, M. C. R. Castro, H. Kanashiro, F. Saito, R. Falci, I. M. Antonopoulos, A. C. Piovesan, W. C. Nahas
2010 Nephrology, Dialysis and Transplantation  

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Background. Sensitized patients (pts) may develop acute antibody-mediated rejection (AMR) due to preformed donor-specific antibodies, undetected by pre-transplant complement-dependent cytotoxicity (CDC) crossmatch (XM). We hypothesized that C4d staining in 1-h post-reperfusion biopsies (1-h Bx) could detect early complement activation in the renal allograft due to preformed donorspecific antibodies. Methods. To test this hypothesis, renal transplants (n = 229) performed between June 2005 and
more » ... ember 2007 were entered into a prospective study of 1-h Bx and stained for C4d by immunofluorescence. Transplants were performed against a negative T-cell CDC-XM with the exception of three cases with a positive B-cell XM.
doi:10.1093/ndt/gfq549 pmid:20844185 fatcat:hmm4eiwpfvaoripenwgizmxezy
Citation

E. David-Neto, D. S. R. David, G. F. Ginani, H. Rodrigues, P. S. Souza, M. C. R. Castro, H. Kanashiro, F. Saito, R. Falci, I. M. Antonopoulos, A. C. Piovesan, W. C. Nahas. "C4d staining in post-reperfusion renal biopsy is not useful for the early detection of antibody-mediated rejection when CDC crossmatching is negative." Nephrology, Dialysis and Transplantation 26.4 (2010) 1388-1392