Axial Preferences in Allylation Reactions via the Zimmerman–Traxler Transition State

Tom Mejuch, Noga Gilboa, Eric Gayon, Hao Wang, K. N. Houk, Ilan Marek
2013 Accounts of Chemical Research  
CONSPECTUS The reaction of substituted allylmetal on prostereogenic carbonyl compound can give rise to up to two racemic diastereomers (syn and anti). Classically, when anti selectivity was observed from pure E-isomers while the Z-isomers exhibit syn-selectivity, the empirical Zimmerman -Traxler
doi:10.1021/ar4000532 pmid:23672428 pmcid:PMC3714348 fatcat:kjidm5ibgjb4vlv3flpqubcl2a