Small Particle-Size Talc Is Associated with Poor Outcome and Increased Inflammation in Thoracoscopic Pleurodesis

Elena Arellano-Orden, Auxiliadora Romero-Falcon, José Martin Juan, Manuel Ocaña Jurado, Francisco Rodriguez-Panadero, Ana Montes-Worboys
2012 Respiration  
after talc) occurred in 8 of 103 patients in the ST and in 1 of 124 in the 'large-particle talc' group (p = 0.007). Patients who received ST had significantly higher proinflammatory cytokines in pleural fluid and serum after talc application, and also in supernatants of the in vitro study. Pleural tumor burden correlated positively with proinflammatory cytokines in serum, suggesting that advanced tumor states induce stronger systemic reactions after talc application. Conclusions: ST provokes a
more » ... trong inflammatory reaction in both pleural space and serum, which is associated with a higher rate of early deaths observed in patients receiving it.
doi:10.1159/000342042 pmid:23018589 fatcat:p2o24prjhrbpvoxn6u4sezzmca