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Minimal mechanistic component of proteasome activation and prevention of impairment by pathological oligomers
Impairment of proteasomal function has been implicated in neurodegenerative diseases, justifying the need to understand how the proteasome is activated for protein degradation. Here, using biochemical and structural (cryo-EM) strategies in both archaeal and mammalian proteasomes, we further determine the HbYX(-motif)-dependent mechanism of proteasomal activation used by multiple proteasome-activating complexes including the 19S Particle. We identify multiple proteasome α subunit residuesdoi:10.21203/rs.3.rs-900719/v1 fatcat:qdagvikg2rd7lhnnclhjf4ckja