Immunochemical Studies on the Poly-γ-D-Glutamyl Capsule of Bacillus Anthracis

Georges E. Roelants, Laura F. Whitten, Ann Hobson, Joel W. Goodman
1969 Journal of Immunology  
The fate and distribution of tritiated poly-γ-d-glutamic acid in immunogenic and nonimmunogenic forms in rabbits with circulating anti-polypeptide antibody was compared with that in normal animals, in order to assess the role of antibody in the splenic retention of immunogens. The presence of circulating antibody did not appreciably modify the retention of either form of the polypeptide. The feature which was consistently associated with immunogenicity of the antigen was the retention in spleen
more » ... of appreciably more labeled material, chemically identified as undegraded poly-γ-d-glutamic acid. In conjunction with other studies, these results suggest that the trapping in lymphoid organs of intact antigen molecules may be of crucial importance for immune induction.
doi:10.4049/jimmunol.103.5.937 fatcat:jwxeyyjk7rejrlakpa6s77z3gq