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The fate and distribution of tritiated poly-γ-d-glutamic acid in immunogenic and nonimmunogenic forms in rabbits with circulating anti-polypeptide antibody was compared with that in normal animals, in order to assess the role of antibody in the splenic retention of immunogens. The presence of circulating antibody did not appreciably modify the retention of either form of the polypeptide. The feature which was consistently associated with immunogenicity of the antigen was the retention in spleendoi:10.4049/jimmunol.103.5.937 fatcat:jwxeyyjk7rejrlakpa6s77z3gq