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The deterministic force of natural selection and stochastic influence of drift shape RNA virus evolution. New deep-sequencing and microfluidics technologies allow us to quantify the effect of mutations and trace the evolution of viral populations with single-genome and single-nucleotide resolution. Such experiments can reveal the topography of the genotype-fitness landscapes that shape the path of viral evolution. By combining historical analyses, like phylogenetic approaches, withdoi:10.1016/j.chom.2018.03.012 pmid:29649440 pmcid:PMC5908228 fatcat:ehu7hkibfrhk7iniselppnb3ea