Different In Situ Distribution Patterns of Dendritic Cells Having Langerhans (T6+) and Interdigitating (RFD1+) Cell Immunophenotype in Psoriasis, Atopic Dermatitis, and Other Inflammatory Dermatoses

Jan D. Bos, Iris D. van Garderen, Suze R. Krieg, Len W. Poulter
1986 Journal of Investigative Dermatology  
Dendritic cells bea ring Langerhans cell (OKT6 +) or interdigi tatin g cell (RFDl +) immunophenotype m ay be reg ularly detected w ithin th e dermis of chronic skin diseases characterized by a lymphohistio cytic (lymphoreticular) infiltrate. T hese 2 subsets of antigen-presenting cell s within the dermis of lesions of exacerbating chronic plaque psoriasis, exacerbating nummul ar dermatitis (dis coid eczema), atopic dermatitis, allergic contact derm atitis, pityriasis [Qsea, li chen ruber planu
more » ... , and cutaneo us lupus erythem,atosus were quantified using co mputer-assisted morphometry. T he m ean dendrite length per derm al dendritic ceIJ w as signifIcantly hi gher for RFDl th an for OKT6 (74.4 ± 0.98 /-L111 vs 70.0 ± 1.26 /-Lm : p = 0.0023). The mean dendrite leng th per derm al dendriti c cell was remarkably constant for each marker in the various diagnostic categories studied. D isease-specific patterns of total dendrite length and number (expressed per 100 infiltrating mononuclear cells)
doi:10.1111/1523-1747.ep12524811 pmid:3734488 fatcat:cluq6vsowjavhpt3hpi6z755qq