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CCAAT/enhancer-binding protein β (C/EBPβ) expression regulates oxidized low-density lipoprotein (ox-LDL) -induced inflammation in macrophages
2018
Medical Journal of Chinese People's Liberation Army
Objective To investigate the role of CCAAT/enhancer binding protein β (C/EBPβ) in the production of IL- 1β induced by oxidized low-density lipoprotein (ox-LDL) in macrophages. Methods Macrophages RAW264.7 cell line treated with 0, 25, 50 and 100μg/ml ox-LDL for 12, 24 and 48h, 0μg/ml ox-LDL at each time point served as a control group, and then 50μg/ml ox-LDL treated for 24h was selected for subsequent experiments. Small interfering RNAs (siRNAs) were used to silence C/EBPβ as well as
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