A Molecular Mechanism for GBF1 Recruitment to cis-Golgi Membranes

Douglas Quilty
ADP--ribosylation factors (Arfs) play a central role in the regulation of vesicular trafficking through the Golgi. Arfs are activated on cis--Golgi membranes exclusively by the guanine nucleotide exchange factor (GEF) Golgi--specific BFA resistance factor 1 (GBF1), upon recruitment from cytosol. Membrane association of Arf is essential for its activation; therefore the recruitment of GBF1 to cis--Golgi
doi:10.7939/r37p8tr8m fatcat:jdjrpq7afrdbxntpqri7ah6bz4