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Lyophilized autologous serum stabilized with sucrose promotes the proliferation and migration of keratinocyte
2020
Journal of Applied Pharmaceutical Science
The autologous serum is widely used as therapy for epithelial cell treatment and dry eye syndrome due to its epitheliotropic properties, which are similar to tears. The serum contains human epidermal growth factor (hEGF) and retinol, which play important roles in cell proliferation and differentiation. Freeze-drying improves the stability of therapeutic proteins for long-term storage. Sucrose is known to stabilize protein during freeze-drying and storage. Also, antioxidants such as vitamin E
doi:10.7324/japs.2021.110712
fatcat:avbmvhgk2za2rod5p26tfo62ga