The principles followed within the MES-CoBraD Project can be generalized for the assessment and management of other Chronic Complex Conditions (CCC) by exploiting advanced analytics modules and RWD acquisition protocols. Work Package 4 (WP4) defines the methodological process for the analysis of the RWD acquired during pilot data acquisition (WP8) to address the challenges faced in CoBraD and share the results within the Consortium and through scientific publications prior to wider

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... (WP9). It is one of three WPs (WP4, WP6, WP8) serving scientific objectives whose tasks were distributed for operational efficiency and minimization of errors. To achieve these goals, eight Work Groups (WG) have been established and organized into three main categories: Complex Brain Disorders, Real World Data and Science of Science work groups. In this deliverable, we present the initial agreed upon scientific aims and hypotheses to be tested through specific proposed analyses, as suggested during each WG's activities. Re-evaluation of the suggested hypotheses and methodologies, results, publications, and new hypotheses will be included in future updates of this deliverable (D4.3-D4.5). The final update of the deliverable (D4.6) will present the final outcome of WP4, providing the summary of all scientific publications that resulted in the project, including the final Guidelines for Diagnosis of CoBraD, as well as Guidelines on Safety and Efficacy of Real-World Medical Therapies.