A COMPARATIVE STUDY OF EFFICACY AND SAFETY OF LORNOXICAM AND DICLOFENAC AS POSTOPERATIVE ANALGESICS AFTER MASTOIDECTOMY SURGERY

R. Nalini, J. Ezhilramya
2017 International Journal of Pharmacy and Pharmaceutical Sciences  
<p><strong>Objective</strong>:<strong> </strong>The objective of the research was to evaluate the efficacy and safety of lornoxicam compared to diclofenac in the management of postoperative pain following mastoidectomy surgery.<strong> </strong></p><p><strong>Methods: </strong>The present study was a<strong> </strong>prospective, single-blinded, randomised study. 80 mastoidectomy patients were randomised into two groups. Group A received lornoxicam 8 mg and group B received diclofenac 75 mg
more » ... iclofenac 75 mg intramuscularly twice daily for 3 consecutive days. The primary parameter was to analyse the postoperative pain using visual analogue scale (VAS) and Wong Bakers scale (WBS). The secondary parameters were the usage of rescue medication and time to use rescue medication.</p><p><strong>Results</strong>:<strong> </strong>There was a significant reduction in the postoperative pain in the lornoxicam group than the diclofenac group (p value&lt;0.05) throughout the study. Significantly 11 patients required rescue medication in diclofenac group, 3 patients in lornoxicam group. No serious adverse event was noted in two groups.</p><p><strong>Conclusion: </strong>Lornoxicam 8 mg was a better analgesic than diclofenac 75 mg in efficacy and safety in the management of postoperative pain following mastoidectomy surgery.</p>
doi:10.22159/ijpps.2017v9i2.15091 fatcat:xflsxvezorb4jolhpui5pmj7iy