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A b s t r a c t We report 5 cases of sclerosing rhabdomyosarcoma. The patients included 4 adults and 1 adolescent. In the 5 cases, 3 tumors occurred in the head and neck region and 2 in an extremity. Histologically, all 5 tumors were characterized by the presence of abundant extracellular hyaline matrix, mimicking osteoid or chondroid tissue. They were composed mostly of primitive small round cells that displayed diverse growth patterns. In 2 cases, focal areas suggestive of spindle celldoi:10.1309/ep3frry6gmp555qc pmid:18285263 fatcat:5r3k7fizkrfdfawj2x7xqnkjvy