Lung Function Trajectories: a New Framework to Understand Adult Chronic Respiratory Diseases

Álvar Agustí, Rosa Faner
2020 Barcelona Respiratory Network  
Lungs grow and mature in utero and after birth until early adulthood. Normally, lung function reaches a peak between 20-25 years of age, earlier in females, and after a relatively brief plateau, it declines slowly due to physiological lung ageing. There are several genetic and environmental factors with the potential to alter this normal lung function trajectory, so it is now recognized that in the general population there is indeed a range of them. Further, it is also known now that some of
more » ... now that some of these trajectories have important health consequences, both for the lungs but also for other organ systems, including premature death. Here we provide a brief overview of these new concepts and discuss the potential implications of this new framework to understand adult respiratory diseases. (BRN Rev. 2020;6(2):118-27) Corresponding author: Alvar Agustí,
doi:10.23866/brnrev:2020-0006 fatcat:755kaailuva3tmrba5vrf2g5hq