Interleukins and their signaling pathways in the Reactome biological pathway database

Steve Jupe, Keith Ray, Corina Duenas Roca, Thawfeek Varusai, Veronica Shamovsky, Lincoln Stein, Peter D'Eustachio, Henning Hermjakob
<span title="">2018</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="" style="color: black;">Journal of Allergy and Clinical Immunology</a> </i> &nbsp;
Background-There is a wealth of biological pathway information available in the scientific literature, but it is spread across many thousands of publications. Alongside publications that contain definitive experimental discoveries are many others that have been dismissed as spurious, found to be irreproducible, or are contradicted by later results and consequently now considered controversial. Many descriptions and images of pathways are incomplete stylized representations that assume the
more &raquo; ... is an expert and familiar with the established details of the process, which are consequently not fully explained. Pathway representations in publications frequently do not represent a complete, detailed, and unambiguous description of the molecules involved; their precise posttranslational state; or a full account of the molecular events they undergo while participating in a process. Although this might be sufficient to be interpreted by an expert reader, the lack of detail makes such pathways less useful and difficult to understand for anyone unfamiliar with the area and of limited use as the basis for computational models. Objective-Reactome was established as a freely accessible knowledge base of human biological pathways. It is manually populated with interconnected molecular events that fully detail the This is an open access article under the CC BY license
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="">doi:10.1016/j.jaci.2017.12.992</a> <a target="_blank" rel="external noopener" href="">pmid:29378288</a> <a target="_blank" rel="external noopener" href="">pmcid:PMC5927619</a> <a target="_blank" rel="external noopener" href="">fatcat:oy2ctphdqbehffj37pps24hsi4</a> </span>
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