Comparative In vitro Anthelmintic Activity of Aqueous and Organic Extract of Root and Bark of Punica Granatum Linn

Atul A Baravkar, Madhukar V Shende, Nilesh A Nalawade, Nitin B. Aher
2020 International Journal of Current Research and Review  
Punica granatum (Punicaceae) has a wide variety of medicinal application owing to its different parts such as leaves, the rind of the fruits, seeds, roots, stems, bark. Up till now very less or no research has been done on the comparative evaluation of the anthelmintic activity of the bark and roots of Punica granatum. Aim: This research study aimed to evaluate aqueous and organic extracts of bark and root of Punica granatum for their anthelmintic activity using Indian adult earthworm called
more » ... earthworm called Pheretima Posthuma and to perform comparative evaluation between aqueous and organic extract. Methods: Different concentrations of aqueous and organic extract ranging from 10 to 100 mg/ml were made and tested on a said earthworm. These extracts were tested for bioassays which includes time for paralysis and time for the death of the worms. Results: Aqueous as well as organic extract of bark exhibited strong anthelmintic activity at a concentration of 100 mg/ml as compared to the root. Lower concentrations did not produce significant anthelmintic activity. The standard reference drug which is used for comparing the anthelmintic activity of these extracts was piperazine citrate at a concentration of 10 mg/ml. Conclusion: Both aqueous and organic extracts of bark and root of Punica granatum are evaluated for and showed potential anthelmintic activity.
doi:10.31782/ijcrr.2020.122404 fatcat:xgq7kfaq5jdg3cmotuzvkkg7je