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Multiple response elements and differential p53 binding control Perp expression during apoptosis
2003
Molecular Cancer Research
The p53 tumor suppressor gene responds to cellular stress by activating either cell cycle arrest or apoptosis. A growing number of target genes involved in each of these pathways have been identified. However, the mechanism by which the apoptosis versus arrest decision is made remains to be elucidated. Perp is a proapoptotic target gene of p53 expressed to high levels in apoptotic cells compared with those undergoing cell cycle arrest. This pattern of expression is unusual among p53 target
pmid:14707288
fatcat:wfijqgrlcfco5iltjpkkxc3kuu