Clinical and epidemiological aspects of microcephaly in the state of Piauí, northeastern Brazil, 2015‐2016

Isabel Marlúcia Lopes Moreira de Almeida, Carmen Viana Ramos, Danielle Carvalho Rodrigues, Amanda Carvalho de Sousa, Maria de Lourdes Cristina Alcântara Paz Carvalho do Nascimento, Marcos Vilhena Bittencourt da Silva, Francisca Miriane Araújo Batista, Jéssica Pereira dos Santos, Roselane Sampaio de Oliveira, Filipe Augusto de Freitas Soares, Samanta Cristina das Chagas Xavier, Filipe Anibal Carvalho‐Costa
2019 Jornal de Pediatria (Versão em Português)  
Objectives: To describe aspects of the microcephaly epidemic in the state of Piauí. Methods: All cases of congenital microcephaly confirmed in the state between 2015 and 2016 were included (n = 100). Investigation forms of the Regional Reference Center for Microcephaly were reviewed. Discarded cases (n = 63) were used as a comparison group. Results: In October, November, and December 2015 incidence rates reached 4.46, 6.33 and 3.86/1000 live births, respectively; 44 cases were reported in the
more » ... ate capital. Among the mothers of confirmed and discarded cases, the frequency of skin rash during pregnancy was 50/97 (51.5%) and 8/51 (15.7%), respectively (p < 0.001); 33 confirmed cases (35.9%) had a head circumference z-score between −2 and −3, 23 (25%) between −3 and −4, and 8 (8.7%) had a z-score of less than −4. Head computer tomography scans revealed calcifications in 78/95 (82.1%) cases. Lissencephaly, hydrocephalus and agenesis of the corpus callosum were also frequently observed. Ophthalmic findings included retinal pigment epithelium rarefaction and atrophy. Absence of otoacoustic emissions was observed in 21/70 cases. One newborn also presented lower limb muscle atrophy. There were no significant differences in vaccination rates for influenza, diphtheria-tetanus-acellular pertussis, and hepatitis B in either group.
doi:10.1016/j.jpedp.2018.08.009 fatcat:ixoxgpt4jrhvfbftr5hcq7xpam