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Inactivation of Myelin-Associated Glycoprotein Enhances Optic Nerve Regeneration
Journal of Neuroscience
CNS regeneration in higher vertebrates is a long sought after goal in neuroscience. The lack of regeneration is attributable in part to inhibitory factors found in myelin (Caroni and Schwab, 1988a). Myelin-associated glycoprotein (MAG) is an abundant myelin protein that inhibits neurite outgrowth in vitro (McKerracher et al., 1994; Mukhopadhyay et al., 1994), but its role in regeneration remains controversial. To address this role, we performed nerve crush on embryonic day 15 chick retina-opticdoi:10.1523/jneurosci.23-08-03112.2003 pmid:12716917 fatcat:fjvoqms235b2vjeonc2beh5ina