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In clinical practice, physicians make a series of treatment decisions over the course of a patient's disease based on his/her baseline and evolving characteristics. A dynamic treatment regime is a set of sequential decision rules that operationalizes this process. Each rule corresponds to a decision point and dictates the next treatment action based on the accrued information. Using existing data, a key goal is estimating the optimal regime, that, if followed by the patient population, woulddoi:10.1214/13-sts450 pmid:25620840 pmcid:PMC4300556 fatcat:wbofrw46qrb7jeavcv742l4lze