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p53 modulates BLM and WRN helicase activities 1 JBC Papers in Press. Published on June 21, 2002 as Manuscript M204111200 SUMMARY BLM, WRN and p53 are involved in the homologous DNA recombination pathway. The DNA structure-specific helicases, BLM and WRN, unwind Holliday junctions (HJ), an activity that could suppress inappropriate homologous recombination during DNA replication. Here, we show that purified, recombinant p53 binds to BLM and WRN helicases and attenuates their ability to unwinddoi:10.1074/jbc.m204111200 pmid:12080066 fatcat:jqw6am36qrdeze6urymmf3j34e