Isoniazid is one of the very important drugs used in antitubercular therapy. Pancreatitis is an uncommon adverse effect of isoniazid. Our case highlights the need for treating physicians to maintain a high level of vigilance while following up patients who are on antitubercular therapy in order to recognize symptoms related to this rare adverse event at an early stage. Immediate drug withdrawal and ensuring isoniazid free course of treatment in future is warranted when a patient develops this adverse event.