Dissociations between microstructural and functional hierarchies within regions of transmodal cortex [article]

Casey Paquola, Reinder Vos de Wael, Konrad Wagstyl, Richard Bethlehem, Jakob Seidlitz, Seok-Jun Hong, Ed Bullmore, Alan Evans, Bratislav Misic, Daniel Margulies, Jonathon Smallwood, Boris Bernhardt
<span title="2018-12-07">2018</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
While the role of cortical microstructure in organising neural function is well established, it remains unclear how structural constraints can give rise to more flexible elements of cognition. While non-human primate research has demonstrated a close structure-function correspondence, the relationship between microstructure and function remains poorly understood in humans, in part because of the reliance on post mortem analyses which cannot be directly related to functional data. To overcome
more &raquo; ... s barrier, we developed a novel approach to model the similarity of microstructural profiles sampled in the direction of cortical columns. Our approach was initially formulated based on an ultra-high-resolution 3D histological reconstruction of an entire human brain and then translated to myelin-sensitive MRI data in a large cohort of healthy adults. This novel method identified a system-level gradient of microstructural differentiation traversing from primary sensory to limbic regions that followed shifts in laminar differentiation and cytoarchitectural complexity. Importantly, while microstructural and functional gradients described a similar hierarchy, they became increasingly dissociated in transmodal default mode and fronto-parietal networks. Meta analytic decoding of these topographic dissociations highlighted associations with higher-level aspects of cognition such as cognitive control and social cognition. Our findings demonstrate a relative decoupling of macroscale function from cortical microstructure in transmodal regions, which likely contributes to the flexible role these regions play in human cognition.
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