Extracting Biomarker Information Applying Natural Language Processing and Machine Learning

Md. Tawhidul Islam, Mostafa Shaikh, Abhaya Nayak, Shoba Ranganathan
2010 Bioinformatics and Biomedical Engineering (iCBBE), International Conference on  
In this paper, we detail an approach to a very specific task of information extraction namely, extracting biomarker information in biomedical literature. Starting with the abstract of a given publication, we first identify the evaluative sentence(s) among other sentences by recognizing words and phrases in the text belonging to semantic categories of interest to bio-medical entities (i.e., semantic category recognition). For the entities like, protein, gene and disease, we determine whether the
more » ... statement refers to biomarker relationship (i.e., assertion classification). Finally, we identify the biomarker relationship among the biomedical entities (i.e., semantic relationship classification). The system, Biomarker Information Extraction Tool (BIET) implements Machine Learning-based biomarker extraction using support vector machines (SVM). The system is trained and tested on a corpus of oncology related PubMed/MEDLINE literatures hand-annotated with biomarker information. We investigate the effectiveness of different features for this task and examine the amount of training data needed to learn the biomarker relationship with the entities. Our system achieved an average Fscore of 86% for the task of biomarker information extraction comparing to the human annotated dataset (i.e. gold standard) scores.
doi:10.1109/icbbe.2010.5514717 fatcat:jeuiavsuibfq3exbcbisimkebe