Synthesis and antiproliferative activity in vitro of new 2-aminobenzimidazole derivatives. Reaction of 2-arylideneaminobenzimidazole with selected nitriles containing active methylene group

Anna Nowicka, Hanna Liszkiewicz, Wanda P. Nawrocka, Joanna Wietrzyk, Katarzyna Kempińska, Andrzej Dryś
2014 Central European Journal of Chemistry  
There are c.a. 50 derivatives of 2-aminobenzimidazole registered in the world as drugs with anticancer, antiviral, antifungal, anthelmintic and antihistamine properties [1]. Based on a review of the chemical literature, derivatives of 2-aminobenzimidazole showed multipharmacological effects such as hypotensive effect [2], anti-inflammatory effects [3], analgesic [4] or antiaggregatory [5] activity. Some chemical compounds, which contain in their structure 2-aminobenzimidazole motif inhibit
more » ... degeneration and in the future they may be used in a treatment of Alzheimer's disease or Parkinson's disease [6]. Recently, a lot of literature has revealed that 2-amino-1H-benzimidazole derivatives could effectively inhibiting the growth of various microorganisms, which suggest that 2-aminobenzimidazole compounds should have large potential as a new type of antibacterial [7], antifungal [8] or antiviral [9] agents. Some of 2-amino-1H-benzimidazole derivatives possess nonmedical use eg. anticorrosive or antifungal agents. They are also common ligands in coordination chemistry.
doi:10.2478/s11532-014-0533-3 fatcat:yjiqtl6jjfa4bncw35ed6d75bm