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Synthesis and antiproliferative activity in vitro of new 2-aminobenzimidazole derivatives. Reaction of 2-arylideneaminobenzimidazole with selected nitriles containing active methylene group
2014
Central European Journal of Chemistry
There are c.a. 50 derivatives of 2-aminobenzimidazole registered in the world as drugs with anticancer, antiviral, antifungal, anthelmintic and antihistamine properties [1]. Based on a review of the chemical literature, derivatives of 2-aminobenzimidazole showed multipharmacological effects such as hypotensive effect [2], anti-inflammatory effects [3], analgesic [4] or antiaggregatory [5] activity. Some chemical compounds, which contain in their structure 2-aminobenzimidazole motif inhibit
doi:10.2478/s11532-014-0533-3
fatcat:yjiqtl6jjfa4bncw35ed6d75bm