rhis b aprePdnt ofapaper intended torput__tion Inajmm_orprcmeeolr_. Since _changes may bemade before publication, this prei:_nt ismade available wt_g_e und_ a'_at itw=notbedted orreproduced wflhout g'w permlssl_ ofg_e _. MAR11 199k _ls'mtmmoN oFTHz,S DOCUMEN'r ,SUNL,M_rEoO S "r I DISCLAIMER This document was prepared as an account of work sponsored by an agency oCthe United States Government. Neither the United States Government nor the University of California nor any of their employees, makes

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... any warranty, express or implied, or assumes anylegalliabilityor responsibilityfortheaccuracy,completeness, orusefulness of any information, apparatus, product, or process disdmed, or represents thatits use would not infringe privatelyowned rights. Rderence herein to any specificcommercial products, process, or service by trade r.ame,trademark, manufacturer, or otherwise, does not necessarily constitute or Implyit_ endorsement, recommendation, orfavoring by the United States Government or the University uf California. The views and opinions of authors expressed herein do not necessarily state or reflect those of'the United States Government or the University of California, and shall not be used for advertising or product endorsement purposes. ABSTRACT The goalof thiseffort is to quickly obtainas many chromosome-specificcDNAs with as much map and sequence detail as possible. Many techniques have been proposed to isolate, and identify geneswithin defined genomic regions; the techniquediscussed here is direct hybridization of a relatively complex genornicprobe, an entire cosmid clone, to eDNA libr_es. This methodcontinuesto be a straightforward techniquewith a ' fair number of successes. "