ONE-DIMENSIONAL MODEL OF SOMITIC CELLS POLARIZATION IN A BISTABILITY WINDOW OF EMBRYONIC MESODERM

VALKO PETROV, JENS TIMMER
2009 Journal of Mechanics in Medicine and Biology  
The considerations are based on the understanding that somitic cells polarization in bistability window of embryonic (pre-somitic) mesoderm is a dynamical process. It occurs in the form of a polarization wavefront of somite cells spread in anterior-posterior direction of the embryonic mesoderm. It is assumed that a macroscopic cell polarization has a bistable behavior corresponding to the molecular mechanism of bistability window formation. Moreover this type of polarization is supposed to be
more » ... ansmittable to the other cells by contact interaction. At the end, a volume of polarized cells is taken, which is able to create mechanical tension in the volume of nonpolarized neighbor cells and to inhibit their polarization. On this basis we explore the leading aspect of somitogenesis robustness by considering a simple wavefront model of polarization and analyzing its propagation in terms of the standard methods of qualitative theory of differential equations. The obtained theoretical results are interpreted in the context of their possible experimental verification.
doi:10.1142/s0219519409003061 fatcat:z6pcdyhzibhu7ja7onnrxlacnm