The use of 90Y-PET imaging in evaluation of 90Y-microspheres distribution in the liver: initial results

Piotr Piasecki, Krzysztof Brzozowski, Piotr Zięcina, Zbigniew Podgajny, Anna Budzyńska, Jan Korniluk, Grzegorz Kamiński, Mirosław Dziuk
2015 Nuclear Medicine Review  
BACKGROUND: Selective internal radiation therapy (SIRT) with 90 Y-microspheres infusion into the hepatic artery is a novel method for palliative treatment of primary and metastatic liver cancer. The post-procedural 90 Y dose estimation in the liver is very difficult because direct measurement of b particles is not possible with SPECT/CT. New methods are needed to assess the 90 Y-microspheres liver distribution. In the present paper we evaluate the 90 Y-PET for these purposes. MATERIALS AND
more » ... DS: A GE Discovery ST PET/CT scanner with a copper ring protected the gantry was used for images acquisition. For SPECT/CT imaging, a GE Infinia VCHWK4 with HEPG collimators was used. The liver 90 Y-microspheres (SIR-Spheres, SIRTEX, Australia) dose distribution after selective internal radiotherapy treatment was evaluated in three patients (9 lesions in total). The activity of 90 Y-microspheres delivered into the liver ranged from 1.0 GBq to 2.2 GBq. The correlations between liver lesions detected with 90 Y-PET, 99m Tc-MAA and 90 -bremsstrahlung were investigated and compared with CT images obtained before and after the procedure. RESULTS: The mean T/N ratio was 2.7 in 99m Tc-MAA, 2.3 in 90 Y-bremsstrahlung and 3.6 in 90 Y-PET. The mean 90 Y absorbed dose in tumor was 133 Gy, 112 Gy, and 187 Gy, respectively. The mean liver tissue radiation was 15.5 Gy. According to RECIST criteria, one PR (mCRC) and two SD were observed (mCRC and PC). Time to progression was 217 and 117 days in two patients with mCRC and 214 days in the patient with PC. CONCLUSIONS: 90 Y-PET/CT images give crucial information regarding 90 Y-microspheres distribution and dosimetry and may serve as a predictor of efficiency of radioembolisation.
doi:10.5603/nmr.2015.0022 pmid:26315870 fatcat:3xabnnwvczavpmxjvrpcgfucue