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Analysis tools for the interplay between genome layout and regulation
2016
BMC Bioinformatics
Genome layout and gene regulation appear to be interdependent. Understanding this interdependence is key to exploring the dynamic nature of chromosome conformation and to engineering functional genomes. Evidence for non-random genome layout, defined as the relative positioning of either co-functional or co-regulated genes, stems from two main approaches. Firstly, the analysis of contiguous genome segments across species, has highlighted the conservation of gene arrangement (synteny) along
doi:10.1186/s12859-016-1047-0
pmid:27294345
pmcid:PMC4905612
fatcat:d7kk4ccnizhwzbi66b5q4v3ijm