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RIC-3 has been identified as a molecule essential for the recruitment of functional nicotinic acetylcholine receptors composed of ␣7, but it exhibits inhibitory effects on ␣4␤2 or ␣3␤4 receptors. In this study, we investigated the role of RIC-3 in the recruitment of 5-hydroxytryptamine type 3A (5-HT 3A ) receptors to the cell surface. Although RIC-3 is not essential for the surface transport of 5-HT 3A receptors, we found that its presence enhances both receptor transport and function in adoi:10.1074/jbc.m414341200 pmid:15809299 fatcat:rkev73fvajarhkcmmkgp4aubgq