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Interaction Studies of a Novel, Water-Soluble and Anti-Cancer Palladim(II) Complex with Calf Thymus DNA
Bulletin of the Korean Chemical Society (Print)
We report the preparation and characterization of a new and water soluble complex of palladium(II) with 1,10-phenanthroline and butyldithiocarbamate ligands. This compound has been studied through spectroscopic techniques, 1 H NMR, IR, electronic spectra and elemental analysis and conductivity measurements. The complex shows 50% cytotoxic concentration (Ic50) value against chronic myelogenous leukemia cell line, K562, much lower than that of cisplatin. Thus the mode of binding of this complexdoi:10.5012/bkcs.2010.31.02.435 fatcat:mmtuaxkgrzglvgxxu5dtlkbtlu