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Loss of keratin expression in anaplastic carcinoma cells due to posttranscriptional down-regulation acting in trans
1992
Cancer Research
Rat keratin K5 and vimentin complementary DNAs have been isolated, identified, and used to study keratin and vimentin expression as markers for cell differentiation. Isologous rat neoplastic epithelial cell lines used were based on a clonal benign epithelial line (A5P/B10) and a clonal anaplastic malignant derivative line (T952/F7). Stable cytoplasmic mRNA was detected for keratin but not vimentin in the benign cells. The anaplastic derivative cells expressed vimentin but showed a 1000-fold
pmid:1384967
fatcat:7fqieri3h5bwtosgkk4g5ttc74