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Glycyrrhizic acid derivatives as influenza A/H1N1 virus inhibitors
2015
Bioorganic & Medicinal Chemistry Letters
This Letter describes the synthesis and antiviral activity study of some glycyrrhizic acid (GL) derivatives against influenza A/H1N1/pdm09 virus in MDCK cells. Conjugation of GL with l-amino acids or their methyl esters, and amino sugar (d-galactose amine) dramatically changed its activity. The most active compounds were GL conjugates with aromatic amino acids methyl esters (phenylalanine and tyrosine) (SI=61 and 38), and S-benzyl-cysteine (SI=71). Thus modification of GL is a perspective route
doi:10.1016/j.bmcl.2015.02.074
pmid:25801933
pmcid:PMC7127794
fatcat:rp4fw72nmfd4fpjw25tifmqdry