Glycyrrhizic acid derivatives as influenza A/H1N1 virus inhibitors

Lidia A. Baltina, Vladimir V. Zarubaev, Lia A. Baltina, Iana A. Orshanskaya, Alina I. Fairushina, Oleg I. Kiselev, Marat S. Yunusov
2015 Bioorganic & Medicinal Chemistry Letters  
This Letter describes the synthesis and antiviral activity study of some glycyrrhizic acid (GL) derivatives against influenza A/H1N1/pdm09 virus in MDCK cells. Conjugation of GL with l-amino acids or their methyl esters, and amino sugar (d-galactose amine) dramatically changed its activity. The most active compounds were GL conjugates with aromatic amino acids methyl esters (phenylalanine and tyrosine) (SI=61 and 38), and S-benzyl-cysteine (SI=71). Thus modification of GL is a perspective route
more » ... in the search of new antivirals, and some of GL derivatives are potent as anti-influenza A/H1N1 agents.
doi:10.1016/j.bmcl.2015.02.074 pmid:25801933 pmcid:PMC7127794 fatcat:rp4fw72nmfd4fpjw25tifmqdry