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X-ray structures of trypsin from bovine pancreas inactivated by diphenyl [N-(benzyloxycarbonyl)amino](4-amidinophenyl)methanephosphonate [Z-(4-AmPhGly) P (OPh) 2 ] were determined at 113 and 293 K to 1.8 Å resolution and refined to R factors of 0.211 (113 K) and 0.178 (293 K). The structures reveal a tetrahedral phosphorus covalently bonded to the Oγ of the active site serine. Covalent bond formation is accompanied by the loss of both phenoxy groups. The D-stereoisomer of Z-(4-AmPhGly) P -(OPh)doi:10.1021/bi9520996 pmid:8605148 fatcat:eh2celt2hbgetn6ryrryt6kkeq