Acute Kidney Injury (AKI) is frequently associated with contrast use and Percutaneous Coronary Angioplasty (PCA) in particular can be more deleterious in this aspect depending on all the clinical aspects of each patient. Aims: Determination of all the significant variables that may be protective or harmful for the incidence of AKI in PCA based on the data of 3662 patients that underwent this procedure. All the medical conditions were described, such as route of access, contrast characteristics,

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... patient preparation, and presence of stable or unstable coronary disease conditions, medications in use, clinical and surgical follow up and outcomes plus length of stay in hospital. Evidence review: PCA is accounted for the occurrence of AKI due to the use of iodinated contrast and also worsened by conditions such as heart failure, diabetes, old age, concomitant use of nephrotoxic medications, among other factors. Place in therapy: Attention must be focused in proper preparation of each patient prior and during the procedure, preference for radial access whenever possible, use of medications, cardiac conditions and medications in use mainly. Conclusion: Prognostic factors associated with increased risk for AKI in PCA were mainly age, previous coronary revascularization, heart failure, use of inotropic medication and length of stay in hospital prior to the PCA. The association with less occurrence of AKI were male gender, stable coronary clinical condition, radial access, use of statins and of angiotensin converting enzyme inhibitors.