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Exploration of beneficial and deleterious effects of inflammation in stroke: dynamics of inflammation cells
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
The inflammatory process during stroke consists of activation of resident brain microglia and recruitment of leucocytes, namely neutrophils and monocytes/macrophages. During inflammation, microglial cells, neutrophils and macrophages secrete inflammatory cytokines and chemokines, and phagocytize dead cells. The recruitment of blood cells (neutrophils and macrophages) is mediated by the leucocyte-endothelium interactions and more specifically by cell adhesion molecules. A mathematical model isdoi:10.1098/rsta.2009.0184 pmid:19884176 fatcat:e4v2ckp5jzh2jn6kgjpqlpbecq