Biological monitoring of uranium exposure in south central Virginia

Shane A Wyatt, Lloyd V Reitz, Timothy R Croley, Dawn Hawkins, Elizabeth Barrett, Allen Mckeown, Nancy Powell, Angela West, Terry Hamner, Michael O Royster
2007 Journal of Exposure Science and Environmental Epidemiology  
In May 2004, two groundwater wells in Dinwiddie County, Virginia were found to have natural uranium levels either at or above the EPA recommended limit of 30 mg/l. As a result, a stop drinking water advisory was issued until a water treatment system could be installed to remove the uranium. In response to residents' concerns, and uncertainty of exposures, affected individuals were asked to participate in a voluntary epidemiological investigation of uranium uptake and 1-year uranium retention
more » ... dy. This study had two primary objectives: quantification of the uranium load on the participants, as expressed by their urine uranium concentration, and retention after 1 year of no exposure. A first-morning void urine specimen, along with survey information, was collected from 156 participants in May 2004, with a second collection occurring 12 months later of 91 participants. The samples were analyzed for uranium by ICP/MS, pH, creatinine by the Jaffe method, and RBP by LIA after both collections. A reduction of one order of magnitude for the geometric mean urine uranium concentration was observed, from 0.100 mg/g creatinine to 0.011 mg/g creatinine in 1 year. Comparatively, NHANES has reported that the geometric mean for all participants, ages 6 years and older, is 0.008 mg/g creatinine, with the 95th percentile being 0.040 mg/g creatinine. None of the second round specimens showed a urine uranium concentration higher than baseline for an individual.
doi:10.1038/sj.jes.7500616 pmid:17928817 fatcat:mbzf7sm7qje6laxcvgm3j6tgj4