The fine-scale genetic structure of the British population

Stephen Leslie, Bruce Winney, Garrett Hellenthal, Dan Davison, Abdelhamid Boumertit, Tammy Day, Katarzyna Hutnik, Ellen C. Royrvik, Barry Cunliffe, Daniel J. Lawson, Daniel Falush, Colin Freeman (+5 others)
2015 Nature  
Fine--scale genetic variation between human populations is interesting as a signature of historical demographic events and because of its potential for confounding disease studies. We use haplotype--based statistical methods to analyse genome--wide SNP data from a carefully chosen geographically diverse sample of 2,039 individuals from the United Kingdom (UK). This reveals a rich and detailed pattern of genetic differentiation with remarkable concordance between genetic clusters and geography.
more » ... he regional genetic differentiation and differing patterns of shared ancestry with 6,209 individuals from across Europe carry clear signals of historical demographic events. We estimate the genetic contribution to SE England from Anglo--Saxon migrations to be under half, identify the regions not carrying genetic material from these migrations, suggest significant pre--Roman but post--Mesolithic movement into SE England from the Continent, and show that in non--Saxon parts of the UK there exist genetically differentiated subgroups rather than a general "Celtic" population.
doi:10.1038/nature14230 pmid:25788095 pmcid:PMC4632200 fatcat:bsigwtw2nvfj7jvmgd327yxyem