Management of Diabetes and Hyperglycemia in Hospitals

S. Clement, S. S. Braithwaite, M. F. Magee, A. Ahmann, E. P. Smith, R. G. Schafer, I. B. Hirsch
2004 Diabetes Care  
A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances. Hyperglycemia and the brain Acute hyperglycemia is associated with enhanced neuronal damage following induced brain ischemia (85-98). Explorat i o n o f g e n e r a l m e c h a n i s m s o f Clement and Associates Penumbral salvage, final infarct size, and functional outcome in patients with median acute BG ranging from 104.4 to 172.8 (5.8-9.6). Study of MRI and
more » ... in acute stroke. Prospective evaluation with serial diffusion-weighted and perfusion-weighted MRI and acute BG measurements. Median acute BG was 133.2 mg/dl (7.4 mmol/l), range 104.4-172.8 mg/dl (5.8-9.6 mmol/l). A doubling of BG from 5 to 10 mmol/l led to a 60% reduction in penumbral salvage and a 56cm 3 increase in final infarct size. In patients with acute perfusion-diffusion mismatch, acute hyperglycemia was also correlated with reduced salvage of mismatch tissue from infarction, greater final infarct size, and worse functional outcome, independent of baseline stroke severity, lesion size, and diabetic status (Obs, n ϭ 63) (110).
doi:10.2337/diacare.27.2.553 pmid:14747243 fatcat:g76yzmbarjepda4vq22m3ew23a