Micro- and nanotechnology approaches for capturing circulating tumor cells

Balaji Panchapakesan, Robert Caprara, Vanessa Velasco, James Loomis, Ben King, Peng Xu, Tom Burkhead, Palaniappan Sethu, L. Jay Stallons, W. Glenn McGregor, Shesh N. Rai, Goetz Kloecker (+1 others)
2010 Cancer Nanotechnology  
Circulating tumor cells (CTC) are cells that have detached from primary tumors and circulate in the bloodstream where they are carried to other organs, leading to seeding of new tumors and metastases. CTC have been known to exist in the bloodstream for more than a century. With recent progress in the area of micro-and nanotechnology, it has been possible to adopt new approaches in CTC research. Microscale and nanoscale studies can throw some light on the time course of CTC appearance in blood
more » ... d CTC over-expression profiles for cancer-related markers and galvanize the development of drugs to block metastases. CTC counts could serve as endpoint biomarkers and as prognostic markers for patients with a metastatic disease. This paper reviews some of the recent researches on using micro-and nanotechnology to capture and profile CTC.
doi:10.1007/s12645-010-0007-z pmid:26069475 pmcid:PMC4452034 fatcat:piuswvosajdkdjilwbntjpvihe