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Living systems have a complex hierarchical organization that can be viewed as a set of dynamically interacting subsystems. Thus, to simulate the internal nature and dynamics of the whole biological system we should use the iterative way for a model reconstruction, which is a consistent composition and combination of its elementary subsystems. In accordance with this bottom-up approach, we have developed MAMMOTh (MAthematical Models of bioMOlecular sysTems) database that allows integratingdoi:10.1101/053652 fatcat:33jw3gcyiff4dfuaoiolcru72u