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Chemotherapy Effectiveness and Prognosis of Gastric Cancer Influenced by PTPN11 Polymorphisms
Cellular Physiology and Biochemistry
Key Words Gastric cancer • PTPN11 • SNP • Chemotherapy •Prognosis • Gene-environment interaction Objective: Since gastric cancer (GC) cells exhibited higher grades of SHP-2 encoded by PTPN11 than normal cells, it would be intriguing to explore whether PTPN11 single nucleotide a Chinese population. Methods: Altogether 430 late-stage GC patients and 960 healthy controls matched with age and sex were incorporated. Three PTPN11 SNPs (i.e. rs7958372, rs12229892 and rs2301756) were genotyped bydoi:10.1159/000447856 pmid:27614952 fatcat:rbaswdpfjreajfopegxhiamqje